When the skin is injured, collagen becomes a comment denominator in the body’s healing response. Collagen helps the body heal itself by preparing the wound bed, balancing wound chemistry, causing cell migration and growth, inducing granulation tissue, and improving overall skin strength. Collagen’s role in these various chemical, mechanical, and biological factors form an environment conducive to wound healing, and ultimately to wound closure.
For many years, the scientific community has identified collagen as a common element in wound healing. Research indicates that collagen plays an important role in the body’s natural healing response.
The Role of Collagen in Wound Healing
Hemostasis
Collagen binds to specific receptor sites on platelet membranes [1] which swell and release substances to initiate hemostasis.[2.3]
Collagen binds to fibronectin,[4,5] causing platelet adhesion and aggregation.6]
Wound Debridement
Collagen is chemotactic to monocytes and leukocytes.[7,8] Monocytes transform into macrophages which scavenge and phagocytize foreign bodies and debris.[9,10
Granulation and Angiogenesis
Collagen attracts monocytes [7,8] which transform into macrophages.Macrophages release substances that result in fibroplasia and angiogenesis.[11]
Collagen provides support for the growth of new capillaries.[11,12] The presence of capillaries is essential for the deposition of new fibers.[11]
Fibroblastic Activity
Collagen binds with fibronectin, [4,5} which promotes cell binding and fibrillogenesis, [15] influences bibarel dimensions, and stimulates fibroblast proliferation and migration.[16]
Collagen is chemotactic to fibroblasts, [17] which govern the restoration of new tissue by depositing oriented and organized fibers.[19.2] Collagen provides a substrate for directed migration and permeation of fibroblasts.[21]
Re-epithelialization
Collagen directly supports the growth, [22,23 attachment,[24] differentiation,[23,24] and migration [25] of keratinocytes.
By binding with fibronectin, [4,5,26,27] collagen provides a provisional matrix for keratinocytesmigration [28].
Wound Remodeling
Collagen and reduce the scarring by depositing oriented and organized fibers [29] and by regulating the amount of collagenase expressed by keratinocytes.[30,32]
Collagen; The Common Denominator and Wound Healing
Wounds should follow the same healing response, but factors such as clinical conditions and complications may alter or help the ideal healing process. In these cases collagen-related activity redirects the wound to the normal healing path.
Injury Occurs and Follows the Normal Healing Path to a Healed Wound
Wound Remodeling
- Coagulating disorder, anticoagulated agents.
- Infection, foreign bodies.
- Immunocompromised, diabetes, venous insufficiency, pressure, pharmacological agents
- Poor nutrition, aging, malignancy.
- Genetic defect, collagen disease
- Unknown complication
Symptoms
- Inadequate hemostasis, delayed healing, poorly formed fibrin network.
- Longer inflammatory response, delayed healing.
- Increase chances of infection, decreased phagocytic activity, altered vascular growth, and inhibition of fibroblasts formation and collagen synthesis, static wound.
- Slow rate of healing decreased collagen synthesis.
- Loss of vascularity, fragile skin, lack of tissue strength.
- Chronic wound
Collagen Related Activity
- Coagulating disorder, anticoagulated agents.
- Infection, foreign bodies.
- Immunocompromised, diabetes, venous insufficiency, pressure, pharmacological agents
- Poor nutrition, aging, malignancy.
- Genetic defect, collagen disease
- Unknown complication
References
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- Hovig T, et al., J. Lab & Clin. Med. 1968;71(1)29-39.
- Zucker MB, et al., Proc. Soc. Exp. Bio. Med. 1962;109:779-787.
- Kleinman HK, et al., BioChem. 1981;20:2325-2330.
- Mosher DF, et al., J. Clin. Invest. 1979;64:781-787.
- Yamada KM, et al., Nature 1978;275:179-184.
- Postlethwaite AE, et al., Proc. Nat. Acad. Sci. USA 1978;75(2):871-875.
- Postlethwaite AE, et al., J Exper. Med. 1976;143:1299 1307.
- Bryant R, J. Enter. Ther. 1987;14(6):262-266.
- Leibovich, SJ, Amer. J Pathol. 1975;78(1):71 91.
- Gogia PP, Ost/Wound Mngt. 1992;38(9):12-20.
- Schor, AM, et al., Int’l J Cancer 1979;24:225 234.
- Yamada KM, et al., Proc. Nat. Acad. Sci. USA 1976;73(4):1217-1221.
- Mosher, DF, Prog. Hemo. Thromb. 1980;5:111-131.
- Grinnell F, et al., J Inves. Derm. 1981,76:181-189.
- Clark RAF, et al., Clin. Res. 1981;29(2):590A.
- Chiang TM, et al., J Clin Invest. 1978;62:916-922.
- Ross R. Biol. Reviews 1968;43(1):51 98.
- Dunn GA, Exp. Cell Res. 1978;111:475-479.
- Tomaseck JT, et al., Dev. Bio. 1982;92:107-122.
- Burton JL, et al., J Enter. Ther. 1987;14(6):262-266.
- Morykwas MJ, et al., J Trauma 1989;29(8):1163-1167.
- Karasek, MA, et al., J Inves. Derm. 1968;51(4):247 252.
- Murray JC, et al., Cell Bio. 1979;80:197-202.
- Emerman JT, et al., In Vitro 1977;13(5):316-327.
- Rouslahti E, et al., BioChem. et Biophys. Acta 1980;631:350-358.
- Engvall E, et al., Int’l J Cancer 1977:20:1-5.
- Clark RAF, et al., J Inves. Derm. 1982:79:264-269.
- .Doillon CJ, et al., Scan. Elect. Micro. 1985;2:897-903.
- .Sudbeck BD, et al., J Biol. Chem. 1994;269(47):30022-30029.
- Parks WC, WOUNDS 1995;7(5):23A-37A.
- Saarialho-Kere UK, et al., J. Clin. Inves. 1993;92:2858 2866.
- Albritton JS, Clin. Pod. Med. & Surg. 1991;8(4):773-785.
- Kollenberg LO, Pod. Today 1995;12:49-62.
- Kollenberg, LO, Pod. Today 1996;1:51-54.
- Kleinman HK, et al., J Cell Bio. 1981;88:473-485.
- Palmieri B, Int’I J Tissue Reaction 1992;14:21-25.38. Mian M, et al.,
- Int’I J Tissue
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Ridley Vann
Mr. Vann oversees E-Commerce, Inventory, and Facilities, ensuring optimal product and supply management across medical, nutraceutical, and cosmetic lines.
With a dedication to accuracy and reliability, he brings a wealth of experience as an innovative project coordinator adept at managing diverse initiatives and streamlining processes.
He holds a Bachelor’s of Science Degree in Environmental Science and Technology from the University of Maryland and started his career at the Smithsonian Institution, spearheading green initiatives for the annual Folklife Festival with the Metropolitan Washington Council of Governments.
Nisha Jain Vann
Creative Director, Human BioSciences
Mrs. Vann is responsible for branding, design, and public outreach efforts for the company.
Mrs. Vann has over five years of experience in the creative design arena. She has spearheaded multiple marketing campaigns, both domestic and international.
She also has experience producing several television and live-stage programs. She has a Bachelor’s Degree in Film and Video Studies from George Mason University.
Jack Slovick
Mr. Slovick is responsible for all regulatory and quality affairs in the company.
Mr. Slovick has worked in regulatory, quality, and clinical services within the medical device and diagnostics industry for nearly 40 years.
He founded Methodize Inc., to offer strategic support for approval of medical devices and in vitro diagnostics products. Mr. Slovick has a Bachelor’s degree in Management Information Systems.
Jigar Patel
Vice President of Operations, Human BioSciences
Mr. Patel is the Vice President of Operations for Human BioSciences. As such, he is responsible for strategy development for optimal growth, organizing multiple teams and implementing optimal product delivery for the growth of HBS.
He has served multiple positions within HBS since 2001, including Operations Manager.
With an MBA in Pharmaceutical Healthcare and a Bachelor’s in Pharmaceuticals, Mr. Patel brings deep technical knowledge in collagen product production with a rich history in managing teams.
David H. Dickieson
General Counsel
Mr. Dickieson, as General Counsel, is involved with Human Biosciences’ efforts to expand internationally while aiding with growth and legal compliance in the U.S.
He has over 40 years of experience as a trial attorney with the U.S. Department of Justice and with Washington, D.C. law firms. His law degree is from the University of Michigan and he received a Bachelors Degree in Government from Cornell.
Dr. Rohan K Jain
President, Human BioSciences
As the President of Human BioSciences, Dr. Rohan K Jain is responsible for the company’s overall operations, with a focus on research and development.
Dr. Jain has supervised and conducted extensive research in the collagen, biomaterials, and protein space, resulting in the release of numerous new products to the market.
Prior to his role at HBS, Dr. Jain was a capital markets attorney at Shearman & Sterling LLP. He received his Doctorate in Law and his MBA from New York University; his Bachelor’s degrees in Biomedical Engineering and Materials Science and his Master’s in Engineering Management from Johns Hopkins University. He is a member of the New York and Maryland bars.