When the skin is injured, collagen becomes a comment denominator in the body’s healing response. Collagen helps the body heal itself by preparing the wound bed, balancing wound chemistry, causing cell migration and growth, inducing granulation tissue, and improving overall skin strength. Collagen’s role in these various chemical, mechanical, and biological factors form an environment conducive to wound healing, and ultimately to wound closure.
For many years, the scientific community has identified collagen as a common element in wound healing. Research indicates that collagen plays an important role in the body’s natural healing response.
The Role of Collagen in Wound Healing
Collagen binds to specific receptor sites on platelet membranes  which swell and release substances to initiate hemostasis.[2.3]
Collagen binds to fibronectin,[4,5] causing platelet adhesion and aggregation.6]
Collagen is chemotactic to monocytes and leukocytes.[7,8] Monocytes transform into macrophages which scavenge and phagocytize foreign bodies and debris.[9,10]
Cleanses the Wound
Establishes New Tissue and Blood Vessels
Granulation and Angiogenesis
Collagen attracts monocytes [7,8] which transform into macrophages.Macrophages release substances that result in fibroplasia and angiogenesis.
Collagen provides support for the growth of new capillaries.[11,12] The presence of capillaries is essential for the deposition of new fibers.
Collagen binds with fibronectin, [4,5} which promotes cell binding and fibrillogenesis,  influences bibarel dimensions, and stimulates fibroblast proliferation and migration.
Collagen is chemotactic to fibroblasts,  which govern the restoration of new tissue by depositing oriented and organized fibers.[19.2] Collagen provides a substrate for directed migration and permeation of fibroblasts.
Create Structural Matrix
Closes the Wound
Collagen directly supports the growth, [22,23 attachment, differentiation,[23,24] and migration  of keratinocytes.
By binding with fibronectin, [4,5,26,27] collagen provides a provisional matrix for keratinocytesmigration .
Collagen and reduce the scarring by depositing oriented and organized fibers  and by regulating the amount of collagenase expressed by keratinocytes.[30,32]
Regains Original Integrity
Collagen; The Common Denominator and Wound Healing
Wounds should follow the same healing response, but factors such as clinical conditions and complications may alter or help the ideal healing process. In these cases collagen-related activity redirects the wound to the normal healing path.
Injury Occurs and Follows the Normal Healing Path to a Healed Wound