The Wound Healing Path
Three different views of the wound healing response
Regardless of size or type, all wounds should follow the same path to healing. Scientific research typically refers to wound healing as a series of overlapping phases. While the body’s complex healing mechanisms occur simultaneously individual areas of a wound may respond at different rates.
Often impediments or complications can slow or halt the healing process in the inflammatory phase of healing. A thorough understanding of the factors affecting wound healing is essential to achieving wound closure. The following information examines some of the elements involved in wound healing.
Clinical View
Native collagen application to wound.
Clinical view
Open abdominal wound, measuring 7x3x3.6cm.
Laboratory view
Day 0-1
Day 0-1- laboratory Leukocytes infiltrate from the underlying tissue to clean up the wound.
- Damaged vessels constrict to slow blood loss.
- Uninjured vessels permeate and release serum, proteins, and platelets.
- Platelets aggregate to stop bleeding.
- Leukocytes migrate into the tissue and initiate the inflammatory process.
Reduced size of wound, measuring 4x1.2x1.5cm.
Day 0-14
Day 0-14 – laboratory New blood vessels grow into the wound to restore circulation.
- Neutrophils secrete chemicals that kill bacteria and mediate inflammatory activities.
- Monocytes emigrate to the wound and are transformed into macrophages.
- Macrophages engulf and digest foreign particles and necrotic debris., including cellular remains.
- Macrophages release angiogenic substances resulting in the growth of new capillaries and granulation tissue.
Reduced wound size measuring 1.3x0.4x0.5cm.
Day 1-35
Day 1-35 – laboratory Macrophages and fibroblasts are present in the wound.
- Fibroblasts proliferate in the wound and secrete glycoproteins and collagen.
- Epidermal cells begin to migrate from the wound edge.
- Granulation tissue is formed from macrophages, fibroblasts, and neovasculature.
Wound Closure. Day 49
Day 5- 90
Day 5- 90 – laboratory Fibroblasts migrate into the wound from surrounding tissue and deposit new collagen fibers. Epidermal cells close the wound.
- Fibroblasts secrete collagen which provides strength to the wound.
- Wound remodeling occurs with the deposition of organized fibers.
- Wound contracture occurs, increasing tissue Integrity.
- Epidermal cells grow over the connective tissue bed to close the wound.
TESTIMONIALS
“I’ve been a disciple of occlusive wound healing ever since”.
Ira Davis, MD, Department of Dermatology,
Westchester County Medical Center, Valhalla, New York
Wound care has changed rapidly since I began my Dermatology training at Duke University. At the time, occlusive dressings were just the beginning to play a significant role in the clinical management of chronic wounds. As a medical student, I utilize wet to dry dressings to treat chronic wounds.
As a Dermatology resident in the light 1980s, I was exposed to advancements and wound healing at Dr. Claude Barton’s Leg Ulcer Clinic at Duke University. In those days, we didn’t have many dressing choices and we utilized occlusive dressings as well as modified Unna’s boots. These methods helped us heal chronic ulcers, and in some cases, enable patients to avoid amputation. It was gratifying to close previously non-healing wounds and help patients enjoy an improved quality of life. I’ve been a disciple of occlusive wound healing ever since.
I treat chronic, non-healing lesions by first determining the etiology of the problem. Then I implement corrective action by selecting a treatment from the broad range of options now available to clinicians. For example, depending on the tissue present in the wound, I will utilize various occlusive dressings. There are also promising Type 1 collagen-based dressings available which may offer a unique methodology to enhance wound healing.
Wound management has advanced significantly since my days as a student using wet-to-dry dressings. Now clinicians have a product armamentarium so diverse that they can select a treatment based on wound clinical characteristics and a dressing’s beneficial attributes.
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Ridley Vann
Mr. Vann oversees E-Commerce, Inventory, and Facilities, ensuring optimal product and supply management across medical, nutraceutical, and cosmetic lines.
With a dedication to accuracy and reliability, he brings a wealth of experience as an innovative project coordinator adept at managing diverse initiatives and streamlining processes.
He holds a Bachelor’s of Science Degree in Environmental Science and Technology from the University of Maryland and started his career at the Smithsonian Institution, spearheading green initiatives for the annual Folklife Festival with the Metropolitan Washington Council of Governments.
Nisha Jain Vann
Creative Director, Human BioSciences
Mrs. Vann is responsible for branding, design, and public outreach efforts for the company.
Mrs. Vann has over five years of experience in the creative design arena. She has spearheaded multiple marketing campaigns, both domestic and international.
She also has experience producing several television and live-stage programs. She has a Bachelor’s Degree in Film and Video Studies from George Mason University.
Jack Slovick
Mr. Slovick is responsible for all regulatory and quality affairs in the company.
Mr. Slovick has worked in regulatory, quality, and clinical services within the medical device and diagnostics industry for nearly 40 years.
He founded Methodize Inc., to offer strategic support for approval of medical devices and in vitro diagnostics products. Mr. Slovick has a Bachelor’s degree in Management Information Systems.
Jigar Patel
Vice President of Operations, Human BioSciences
Mr. Patel is the Vice President of Operations for Human BioSciences. As such, he is responsible for strategy development for optimal growth, organizing multiple teams and implementing optimal product delivery for the growth of HBS.
He has served multiple positions within HBS since 2001, including Operations Manager.
With an MBA in Pharmaceutical Healthcare and a Bachelor’s in Pharmaceuticals, Mr. Patel brings deep technical knowledge in collagen product production with a rich history in managing teams.
David H. Dickieson
General Counsel
Mr. Dickieson, as General Counsel, is involved with Human Biosciences’ efforts to expand internationally while aiding with growth and legal compliance in the U.S.
He has over 40 years of experience as a trial attorney with the U.S. Department of Justice and with Washington, D.C. law firms. His law degree is from the University of Michigan and he received a Bachelors Degree in Government from Cornell.
Dr. Rohan K Jain
President, Human BioSciences
As the President of Human BioSciences, Dr. Rohan K Jain is responsible for the company’s overall operations, with a focus on research and development.
Dr. Jain has supervised and conducted extensive research in the collagen, biomaterials, and protein space, resulting in the release of numerous new products to the market.
Prior to his role at HBS, Dr. Jain was a capital markets attorney at Shearman & Sterling LLP. He received his Doctorate in Law and his MBA from New York University; his Bachelor’s degrees in Biomedical Engineering and Materials Science and his Master’s in Engineering Management from Johns Hopkins University. He is a member of the New York and Maryland bars.