Why Are Medifil II Collagen Particles Different?
Although collagen particles are not new to the market, they have recently become one of the most popular advanced wound care products, particularly among surgeons and podiatric physicians. Collagen particles can be incredibly useful as more physicians and wound care professionals explore more rapid and cost-efficient ways to improve wound healing.
What you remove from a wound (devitalized tissue) is still more significant than what you put on it. However, no matter what you put on a wound, proper wound debridement, offloading, and moisture balance are essential. Keeping a wound free of debris is still significant for wound healing. While the ease of use and low cost are the most evident advantages of collagen particles, the particle form of a collagen protein provides direct bioavailability for the wound bed, promoting wound healing.
Medifil® II Collagen Particles enable increased diffusion across the wound bed’s surface, in addition to quick absorption. The body’s natural tissue repair is stimulated by increased wound contact and bioavailability. A better understanding of collagen’s natural form and function in wound healing has aided practitioners in better understanding their wound healing options.
Medifil® II Collagen Particles are collagen in their “purest form”. Non-hydrolyzed collagen retains a higher percentage of its native triple helix protein structure, providing for greater molecular and scaffold stability during wound healing. To improve thermal endurance, mechanical strength, and the ability to engage in precise interactions with other biomolecules, collagen must maintain its triple helix form.
Type 1 collagen is required for the extracellular matrix to produce growth factors, as well as to store and retain growth factors. When the extracellular matrix is disrupted during hydrolysis, tissue loss and bacterial proliferation are possible. Because the aptitude of macrophages, fibroblasts, and endothelial cells to move and attach themselves is influenced by integrin interaction with collagen, type 1 collagen is required to recruit macrophages and monocytes. Remarkably, the strength of the chemotaxis stimulation is proportional to the amount of collagen present.
Metalloproteases like collagenase, as well as other types of trauma or enzymatic erosion, cause collagen degradation naturally. When this happens, however, the collagen fragments induce macrophage and fibroblast infiltration in the wound bed. Furthermore, the body recycles any exposed amino acids leftover from the fragmentation process and utilizes them to create new proteins for accelerated wound healing.
When collagen molecules fragment (hydrolyzed), their triple helix form is lost, the function shifts to a more rejuvenated condition by activating monocytes, resulting in the creation of more macrophages, and so on. Nonhydrolyzed collagen particles or powders may improve scaffolding and cell migration in forming granulation tissue. In the wound care market, there are many hydrolyzed collagen formats that do not compare to the high collagen protein structure and healing outcomes as do Medifil® II Collagen Particles.
Properties of Medifil® II Collagen Particles
Clinical Indications of Medifil® II Collagen Particles
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