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Non-Hydrolyzed Collagen vs. Hydrolyzed Collagen

Non-Hydrolyzed vs Hydrolyzed Collagen in Wound Healing

Collagen is a foundational triple-helix protein molecule. It remains a pivotal component of the extracellular matrix, providing skin structure and elasticity. In advanced wound care, various collagen products have emerged that promote wound healing. Human BioSciences utilizes only non-hydrolyzed triple-helical bovine collagen in all its wound care supplies. Find out more about why below.

Collagen Technology and Wound Healing

Collagen technology dressings are engineered to inhibit protease activity while transitioning the wound into a healing state. These advanced wound care dressings act as catalysts in preventing wound chronicity, facilitating tissue growth, autolysis, angiogenesis, collagen deposition, and wound re-epithelialization.

Sources of Collagen

Collagen can be derived from various species such as bovine, porcine, equine, piscean, and avian tissues. Its matrix structure is a template for future tissue formation, continually attracting fibroblasts to the wound site. During the maturation stage of healing, collagen is believed to enhance the deposition of oriented collagen fibers, bolstering the tensile strength of new tissue. While technology continues to advance in new methods of collagen production, bovine sources are the most closely recognized and utilized during our human wound-healing process.

Non-Hydrolyzed vs. Hydrolyzed Collagen

Non-hydrolyzed means the collagen maintains its original form. This is the highest, purest, most natural state of collagen, with the highest percentage of its native triple helix protein structure. This preservation provides greater molecular and scaffold stability for the body to absorb during wound healing.
Non-hydrolyzed collagen particles or powders may enhance scaffolding and cell migration during granulation tissue formation. Human BioSciences’ proprietary process protects and retains significantly more native triple helical protein structure in all of their premiere collagen wound care products.

Hydrolyzed collagen is fragmented in nature and cannot form scaffolds independently. These peptides must be combined with copolymers like cellulose and chitosan. Copolymers are typically formed from non-bioavailable “dead proteins” that have undergone an aggressive chemical process and hydrolysis.
Hydrolyzed collagen loses its triple-helical shape when it is broken down into amino acids like glycine, proline, and hydroxyproline. Due to the process of breaking down the molecules, hydrolyzed collagen is often found in supplement form as it is more easily digested and absorbed.

Advancing Wound Healing with Collagen Dressings

Although collagen dressings vary, the overarching goal remains to accelerate wound healing. The wound healing process follows a cascading and overlapping series of phases, including hemostasis, inflammation, proliferation, and remodeling. Collagen dressings aid in maintaining an optimal moist environment throughout the entire process, promoting the deposition of new collagen fibers and supporting tissue regeneration.

A solid wound care program should address the root cause, wound bed preparation, moist wound healing, offloading/redistribution, and education. Collagen dressings have shown promise in advancing and preventing chronic complex wounds beyond traditional care. Healthcare providers should have access to top-quality, advanced products like non-hydrolyzed collagen wound care dressings when determining a care plan for their patients.

Chronic slow or non-healing wounds plague our communities, affecting upwards of 2.5% of the population. This leads to more strain on our healthcare system and declining independence for an individual managing a chronic wound issue. Many people continue to be treated with outdated traditional wound care methods. Utilizing advanced wound care products like Human BioSciences collagen wound sheets, powders, and gels could facilitate improved outcomes for many.


Mathew-Steiner SS, Roy S, Sen CK. Collagen in Wound Healing. Bioengineering (Basel). 2021;8(5):63. Published 2021 May11.

Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-833. doi:10.1002/bip.22486

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About Human BioSciences

Human Biosciences, Inc. is a global biotechnology company specializing in collagen-based products for wound care management. Dr. Manoj Jain founded HBS in 1990 with Kollagen™ technology, pioneering advanced wound care with native non-hydrolyzed Type -1 bovine collagen in its purest form with three delivery modes with Collatek® Collagen Gel, SkinTemp® II Collagen Sheets and Medifil® II Collagen Particles. HBS continues engineering breakthroughs daily with innovative new product development, manufacturing advancements, and global product distribution with facilities in the USA and India.


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