SkinTemp® II Collagen Sheets can stay in place up to 7 days if the cover dressing is not soiled and border is intact. As wounds heal the expectation is the wound will produce less exudate over time and drainage can help determine dressing change intervals. If the wound is producing enough drainage that the cover dressing is saturated, that timing would be appropriate initially. Upon dressing change when the wound appears dry, the interval can be extended. Follow your facility protocols as a basic recommendation.