Venous leg ulcers (VLUs) are caused by blood leaking from veins into the skin, causing the skin to break down or produce an ulcer a hole in the skin forms when blood does not flow through the veins as it should. Both men and women are affected by vascular disease. VLUs are more likely among people who have had a leg injury, have varicose veins or clots in their legs, have had many pregnancies, are obese, or have a job that requires long periods of standing or sitting.
Wearing fitted compression stockings and elevating your legs above your heart are two things you can do to improve or manage venous insufficiency. This will assist in returning blood to the heart. If you wear compression stockings, you should change them every 6 months because they will stretch out over time. The progressive compression won’t be enough. When seated, avoid crossing your legs, and if you must stand for long periods of time at work, shift your weight from one foot to the other. Tight apparel, shoes, garters, girdles, and knee-high socks should all be avoided.
Healing venous leg ulcers (VLUs) frequently reopen. Living a healthier lifestyle, hydrating skin daily, preserving the skin, and maintaining excellent circulation can all assist to prevent ulcers from reappearing (wearing prescribed compression therapy).
Collagen dressings, when used in conjunction with compression therapy bandaging, have been shown to be beneficial in the treatment of difficult-to-heal venous leg ulcers. This also improves the patient’s quality of life.
Collagen Dressing Technology Matters
The purpose of collagen technology dressings is to inhibit protease activity while healing the wound. Collagen advanced wound care dressings are shown to be a catalyst in wound chronicity by promoting tissue growth, autolysis, angiogenesis, collagen deposition, and wound re-epithelialization. Kollagen™ Technology, a unique manufacturing technology developed by Human BioSciences, Inc. (HBS), is used to create HBS products. The collagen triple helix protein molecule shape is retained and kept in its “purest” form through our carefully planned production process, resulting in the best grade collagen products. Understanding functional features such as biomolecular biological activity and modalities are critical when choosing the right collagen dressing and technology. Kollagen™ Technology from HBS is the “only” intact collagen product available in the tissue regeneration industry.
Human BioSciences’s (HBS) collagen is made entirely of non-hydrolyzed type I bovine (cattle) collagen. Non Hydrolyzed collagen preserves substantially more of its native triple helix form, providing for improved molecular stability and scaffolding as wounds progress toward healing. Human BioSciences, Inc. has meticulously bioengineered a patented Kollagen™ technology approach to ensure collagen molecules preserve bioactivity and remain in their purest form, binds, and inactivates excessive MMPs present in chronic wounds.™
Properties and Features of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel
Clinical Indications of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel
Application of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel
The application is simple, and the product is compatible with other topical agents and dressings. If deeper wounds have undermining or tunneling, gently press the product into the spaces loosely.
The frequency of dressing changes is determined by the wound assessment, amount of exudate, physician order, and dressing manufacturer requirements. Depending on the dressing, several wear times, such as 1-7 days, may be offered. A secondary dressing, such as transparent film, composite, hydrocolloid, gauze, or foam, is required for most wounds.
The goal is to provide evidence-based advanced wound care while adhering to established and developed medical standards in order to achieve the best possible wound healing results.
References
Brenner M, Albert P, Raminfard A. Collagen Treatment in the Diabetic Foot. The Diabetic Foot. 2019 November/December. Podiatry Management. https://podiatrym.com/pdf/2019/11/Brenner1119Web.pdf last accessed September 17, 2020.
Gibson DJ, Schultz GS. Molecular Wound Assessments: Matrix Metalloproteinases. Adv Wound Care (New Rochelle). 2013;2(1):18-23. doi: 10.1089/wound.2011.0359
Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-833. doi: 10.1002/bip.22486
Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Badylak SF Transpl Immunol. 2004 Apr; 12(3-4):367-77. Westgate, S., Cutting, K. F., Deluca, G., & Assad, K. (n.d.).
Collagen dressings Made Easy (page 1 of 3) › Made Easy › Wounds UK. Retrieved September 17,2020 from http://www.wounds-uk.com/made-easy/collagen-dressings-made-easy.
Ayello E.A., Baranoski S., Kerstein M.D., Cuddigan J. Wound treatment options. In: Baranoski S., Ayello E.A., editors. Wound Care Essentials: Practice Principles. Lippincott Williams & Wilkins; Philadelphia, PA: 2003. p. 138
León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi:10.3390/molecules24224031
Fleck CA, Simman R. Modern collagen wound dressings: function and purpose. J Am Col Certif Wound Spec. 2011;2(3):50-54. Published 2011 Aug 1. doi: 10.1016/j.jcws.2010.12.003
Human BioSciences, Inc. blog offers education and tips; however,the information provided by this website or company is not a substitute for medical treatment or advice.
Mrs. Vann is responsible for branding, design, and public outreach efforts for the company. Mrs. Vann has over five years of experience in the creative design arena. She has spearheaded multiple marketing campaigns, both domestic and international. She also has experience producing several television and live-stage programs. She has a Bachelor’s Degree in Film and Video Studies from George Mason University.
Mr. Patel is the Vice President of Operations for Human BioSciences. As such, he is responsible for strategy development for optimal growth, organizing multiple teams and implementing optimal product delivery for the growth of HBS. He has served multiple positions within HBS since 2001, including Operations Manager. With an MBA in Pharmaceutical Healthcare and a Bachelor’s in Pharmaceuticals, Mr. Patel brings deep technical knowledge in collagen product production with a rich history in managing teams.
As the President of Human BioSciences, Dr. Rohan K Jain is responsible for the company’s overall operations, with a focus on research and development. Dr. Jain has supervised and conducted extensive research in the collagen, biomaterials, and protein space, resulting in the release of numerous new products to the market. Prior to his role at HBS, Dr. Jain was a capital markets attorney at Shearman & Sterling LLP. He received his Doctorate in Law and his MBA from New York University; his Bachelor’s degrees in Biomedical Engineering and Materials Science and his Master’s in Engineering Management from Johns Hopkins University. He is a member of the New York and Maryland bars.
Cheryl Carver, LPN, WCC, CWCA, CWCP, DAPWCA, FACCWS is responsible for clinical education and training initiatives for customer accounts. Ms. Carver has amassed a wealth of clinical knowledge and industry experience in her more than 20 years as a board-certified wound care nurse. She has authored over 200 published white papers, ebooks, blogs, and articles for WoundSource and freelance.
Dr. Goebel is responsible for the company’s physical infrastructure and global expansion efforts through partnerships. Prior to joining HBS, Dr. Goebel was Managing Director at the Graf Matuschka Group in Munich, Germany, where he was actively involved in restructuring and privatization in East Germany and Eastern Europe. He was also a member of the American group of the EBRD European Bank for Reconstruction and Development in the privatization of the Russian economy and military complex. He has over forty years’ experience in many different industries including medical devices, pharmacy, and others. Dr. Goebel earned his Doctorate and Postdoctoral degrees in Economics in East Berlin.
Mr. Kumar is responsible for the company’s overall accounting and finance activities with a focus on internal control and taxation.
Mr. Kumar has over 25 years of public and corporate accounting experience. He is a Certified Public Accountant, licensed in the State of Virginia, Maryland, and Washington D.C., and an Enrolled Agent authorized to practice before the Internal Revenue Service. Mr. Kumar is also a Chartered Accountant and fellow member of the Institute of Chartered Accountants of India. Mr. Kumar received his Master’s degree in Commerce from Himalayan University in India.
Mr. Slovick is responsible for all regulatory and quality affairs in the company. Mr. Slovick has worked in regulatory, quality, and clinical services within the medical device and diagnostics industry for nearly 40 years. He founded Methodize Inc., to offer strategic support for approval of medical devices and in vitro diagnostics products. Mr. Slovick has a Bachelor’s degree in Management Information Systems.
Mr. Agarwal is responsible for Corporate Business Development, Sales, and Product Development, both locally and internationally for the company. Mr. Agarwal has over six years of corporate sales and business development experience. He completed his Master of Science in Engineering Management degree from Johns Hopkins University with a technical concentration in Mechanical Engineering. In the past, he has also worked as a fundraising volunteer for three years and thus gained insights in community fundraising and business development. Additionally, he has interned at a manufacturing firm and understood various intricacies involved in manufacturing ranging from the floor level to the supply chain. He has published a paper on Omni Channel Supply Chain and is a certified Lean Six Sigma associate. He has also interned as a business development consultant to a startup for market research and pricing strategies in Israel. Equipped with a combination of management and technical background acquired from his diverse experiences and education, he is perfectly suited to lead the business development efforts for Human BioSciences.
