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Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel for Venous Leg Ulcers (VLUs)

Venous leg ulcers (VLUs) are caused by blood leaking from veins into the skin, causing the skin to break down or produce an ulcer a hole in the skin forms when blood does not flow through the veins as it should. Both men and women are affected by vascular disease. VLUs are more likely among people who have had a leg injury, have varicose veins or clots in their legs, have had many pregnancies, are obese, or have a job that requires long periods of standing or sitting.


Wearing fitted compression stockings and elevating your legs above your heart are two things you can do to improve or manage venous insufficiency. This will assist in returning blood to the heart. If you wear compression stockings, you should change them every 6 months because they will stretch out over time. The progressive compression won’t be enough. When seated, avoid crossing your legs, and if you must stand for long periods of time at work, shift your weight from one foot to the other. Tight apparel, shoes, garters, girdles, and knee-high socks should all be avoided.


Healing venous leg ulcers (VLUs) frequently reopen. Living a healthier lifestyle, hydrating skin daily, preserving the skin, and maintaining excellent circulation can all assist to prevent ulcers from reappearing (wearing prescribed compression therapy).


Collagen dressings, when used in conjunction with compression therapy bandaging, have been shown to be beneficial in the treatment of difficult-to-heal venous leg ulcers. This also improves the patient’s quality of life.

Collagen Dressing Technology Matters

The purpose of collagen technology dressings is to inhibit protease activity while healing the wound. Collagen advanced wound care dressings are shown to be a catalyst in wound chronicity by promoting tissue growth, autolysis, angiogenesis, collagen deposition, and wound re-epithelialization. Kollagen Technology, a unique manufacturing technology developed by Human BioSciences, Inc. (HBS), is used to create HBS products. The collagen triple helix protein molecule shape is retained and kept in its “purest” form through our carefully planned production process, resulting in the best grade collagen products. Understanding functional features such as biomolecular biological activity and modalities are critical when choosing the right collagen dressing and technology. Kollagen Technology from HBS is the “only” intact collagen product available in the tissue regeneration industry.

Human BioSciences’s (HBS) collagen is made entirely of non-hydrolyzed type I bovine (cattle) collagen. Non Hydrolyzed collagen preserves substantially more of its native triple helix form, providing for improved molecular stability and scaffolding as wounds progress toward healing. Human BioSciences, Inc. has meticulously bioengineered a patented Kollagen technology approach to ensure collagen molecules preserve bioactivity and remain in their purest form, binds, and inactivates excessive MMPs present in chronic wounds.

Properties and Features of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel

  • Compatibility with topical treatments and various secondary dressings
  • Absorbent qualities
  • Hemostatic characteristics
  • Promotes angiogenesis
    Faster healing rates
  • Lowers MMP levels prevalent in chronic wounds
  • Cuttable – collagen sheets
  • Easy to use in undermining and tunneling – collagen particles
  • Compatible with topicals and dressings
  • Available in a variety of sizes
  • 5-year shelf life

Clinical Indications of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel

  • Acute and chronic wounds, partial and full-thickness wounds
  • Non-infected and infected wounds
  • Light to moderately exudating wounds
  • Do not use on third-degree burns
  • Sensitivities to bovine products

Application of Medifil® II Collagen Particles, Skin Temp® II Collagen Sheets, and Collatek® Gel

The application is simple, and the product is compatible with other topical agents and dressings. If deeper wounds have undermining or tunneling, gently press the product into the spaces loosely.

The frequency of dressing changes is determined by the wound assessment, amount of exudate, physician order, and dressing manufacturer requirements. Depending on the dressing, several wear times, such as 1-7 days, may be offered. A secondary dressing, such as transparent film, composite, hydrocolloid, gauze, or foam, is required for most wounds.
The goal is to provide evidence-based advanced wound care while adhering to established and developed medical standards in order to achieve the best possible wound healing results.


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Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 2014;101(8):821-833. doi: 10.1002/bip.22486

Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Badylak SF Transpl Immunol. 2004 Apr; 12(3-4):367-77. Westgate, S., Cutting, K. F., Deluca, G., & Assad, K. (n.d.).

Collagen dressings Made Easy (page 1 of 3) › Made Easy › Wounds UK. Retrieved September 17,2020 from
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León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031. Published 2019 Nov 7. doi:10.3390/molecules24224031

Fleck CA, Simman R. Modern collagen wound dressings: function and purpose. J Am Col Certif Wound Spec. 2011;2(3):50-54. Published 2011 Aug 1. doi: 10.1016/j.jcws.2010.12.003

Human BioSciences, Inc. blog offers education and tips; however,the information provided by this website or company is not a substitute for medical treatment or advice.

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